Life-Extending Discovery Renews Debate Over Aging as a ‘Disease’
As we get older, NAD+ levels decrease, allowing DNA damage to build up. These mutations aren’t a direct cause of the progressive deterioration associated with aging. Cells cope with the damage by turning on the wrong genes at the wrong time. If NAD+ levels could be increased perhaps the damage could be reversed.
Sinclair and his team tested their theory on a group of older mice with low NAD+ levels. The technology in the animals slows down the appearance of diseases, and that’s how we know that it’s slowing down aging itself. And as a consequence of being healthier, the animals live longer.
Now Sinclair’s team is moving toward human trials of the NAD+ booster, with the hope of getting a drug on the market within the next five years.