Life-Extending Discovery Renews Debate Over Aging as a ‘Disease’

As we get older, NAD+ levels decrease, allowing DNA damage to build up. These mutations aren’t a direct cause of the progressive deterioration associated with aging.  Cells cope with the damage by turning on the wrong genes at the wrong time.  If NAD+ levels could be increased perhaps the damage could be reversed.

Sinclair and his team tested their theory on a group of older mice with low NAD+ levels.  The technology in the animals slows down the appearance of diseases, and that’s how we know that it’s slowing down aging itself. And as a consequence of being healthier, the animals live longer.

Now Sinclair’s team is moving toward human trials of the NAD+ booster, with the hope of getting a drug on the market within the next five years.


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