Creating ‘leaks’ in blood vessels could aid in drug delivery
Gang Bao, a bioengineer at Rice University, and collaborators at Emory University and the Georgia Institute of Technology report using magnets to help iron-oxide nanoparticles invade endothelial cells both in the lab and in vivo. Then they use the same magnets to make vessels temporarily “leaky.”
Fluorescent iron-oxide nanoparticles glow in endothelial cells. At left, the nanoparticles are evenly distributed among the microtubules that help give the cells their shape. At right, after a magnetic field is applied, the nanoparticles are pulled toward one end of the cells and change their shapes.