Could a Diabetes Drug Help Beat Alzheimer’s Disease?
Most of the 20 million people diagnosed with type 2 diabetes in the U.S. take metformin to help control their blood glucose. The drug is ultrasafe. Even in the absence of diabetes, Alzheimer’s patients often have decreased insulin sensitivity in the brain. Brain imaging revealed some improvements in neural metabolism.
Insulin plays many roles in the brain—it is involved in memory formation, and it helps to keep synapses free of protein debris, including the tau tangles and amyloid plaques that build up in Alzheimer’s.